Structure modelling

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By providing distance distribution restraints on length scales between about 1.5 and 8 nanometres, EPR spectroscopy complements other techniques in structural biology. In most cases, the distances are measured between spin labels, so that reliable modelling requires simulation of the conformational distribution of the spin label side group.

Most of the time distance distribution restraints are not sufficient to fully define structure. Therefore, we develop hybrid structure modelling approaches that combine restraints obtained with various experimental techniques.

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Sat Apr 29 18:46:41 CEST 2017
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